BONE and JOINT™ Ingredients Research

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A commercialized dietary supplement alleviates joint pain in community adultsNieman DC, Shanely RA, Luo B, et al. A commercialized dietary supplement alleviates joint pain in community adults: a double- blind, placebo-controlled community trial. Nutr J. 2013. 12:154.
A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis PatientsAmalraj A, Varma K, Jacob J et al . A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel- Group Study. J Med Food. 2017. 20(10):1022-1030.
A pilot randomized, double‐blind, placebo‐controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the kneeMajeed M, Majeed S, Narayanan NK, et al. A pilot, randomized, double-blind, placebo-controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee. Phytother Res. 2019.
A Randomized Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid ArthritisChandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012. 26(11):1719-25.  
Anti-inflammatory and antioxidant activities of cat’s clawSandoval M, Okuhama N, Zhang X et al. Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002. 9(4):325-37.
Assessment report on SalixEuropean Meds Agency. Assessment report on Salix [various species including S. purpurea L., S. daphnoides Vill., S. fragilis L.], cortex. Committee on Herbal Medicinal Products (HMPC). 2017. 1-55.
Benefits of antioxidant supplements for knee osteoarthritisGrover AK, Samson SE. Benefits of antioxidant supplements for knee osteoarthritis: rationale and reality. Nutr J. 2016. 15:1.
Bromelain as a Treatment for Osteoarthritis
Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adultsWalker AF, Bundy R, Hicks SM, et al. Bromelain reduces mild acute knee pain and improves well-being in a dose-dependent fashion in an open study of otherwise healthy adults. Phytomedicine. 2002. 9(8): 681-6.
Cat’s claw An Amazonian vine decreases inflammation in osteoarthritisHardin S. Cat's claw – an Amazonian vine decreases inflammation in osteoarthritis. Complement Ther Clin Pract. 2007. 13(1):25-8.
Cellular pharmacodynamic effects of Pycnogenol in patients with severe osteoarthritis
Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritisKizhakkedath R: Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep. 2013 Nov;8(5):1542-8.
Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the kneeMehta K, Gala J, Bhasale S, et al. Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351]. BMC Complement Altern Med. 2007. 7:34.
Curcuminoid Treatment for Knee Osteoarthritis A Randomized Double-Blind Placebo-Controlled TrialPanahi Y, Rahimnia AR, Sharafi M, et al. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo- controlled trial. Phytotherapy Research. 2014. 28(11): 1625-31.
Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol®) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe OsteoarthritisMülek M, Seefried L, Genest F et al. Distribution of Constituents and Metabolites of Maritime Pine Bark Extract (Pycnogenol ® ) into Serum, Blood Cells, and Synovial Fluid of Patients with Severe Osteoarthritis: A Randomized Controlled Trial. Nutrients. 2017. 9(5):443.
Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combinationMiller M, Mehta K, Kunte S et al. Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]. J Inflamm (Lond). 2005. 2:11.
Effect of pine bark extract Pycnogenol on symptoms of knee osteoarthritis
Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis
Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritisHaroyan A, Mukuchyan V, Mkrtchyan N et al: Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med. 2018 Jan 9;18(1):7.
Efficacy and safety of freeze-dried cat’s claw in osteoarthritis of the kneePiscoya J, Rodriguez Z, Bustamante S et al. Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflamm Res. 2001.50(9):442-8.
Efficacy and safety of plant-derived products for the treatment of osteoarthritisLaslett L, Jin X, Jones G. Efficacy and safety of plant-derived products for the treatment of osteoarthritis. Botanics: Targets and Therapy 2015:5.
Efficacy and Safety of White Willow Bark Salix alba ExtractsShara M, Stohs S. Efficacy and Safety of White Willow Bark (Salix alba) Extracts. Phytother Res. 2015 Aug;29(8):1112-6
Efficacy and Safety of Willow Bark Extract in the Treatment of Osteoarthritis and Rheumatoid ArthritisBiegert C, Wagner I, Lüdtke R et al. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomized double-blind controlled trials. J Rheumatol. 2004 Nov;31(11):2121-30.
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of kneeKimmatkar N, Thawani V, Hingorani L et al: Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double-blind placebo-controlled trial. Phytomedicine. 2003 Jan;10(1):3-7.
Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ OsteoarthritisJayachandran S, Khobre P. Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis- A Randomised Clinical Trial. J Clin Diagn Res. 2017. 11(6): ZC09- ZC11.
Efficacy of Curcuma for Treatment of OsteoarthritisPerkins K, Sahy W, Beckett R. Efficacy of Curcuma for Treatment of Osteoarthritis. J Evid Based Complementary Altern Med. 2016;22(1):156–165
Frankincense systematic reviewErnst E. Frankincense – a systematic review. BMJ 2008. 337:a2813
Herbal Medications Commonly Used in the Practice of RheumatologySetty A, Sigal L. Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects. Semin Arthritis Rheum. 2005. 34(6):773-84.
Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy FrankincenseTausch L, Henkel A, Siemoneit U et al: Identification of human cathepsin G as a functional target of boswellic acids from the anti- inflammatory remedy frankincense. J Immunol. 2009 Sep 1;183(5):3433-42.
Inhibition of NF-κB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol)Grimm T, Chovanová Z, Muchová J, et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond). 2006. 3:1.
Natural antiinflammatory agents for pain relief in athletesMaroon C, Bost J, Borden M et al. Natural antiinflammatory agents for pain relief in athletes. Neurosurg Focus . 2006. 21(4):E11.
Oral herbal therapies for treating osteoarthritisCameron M, Chrubasik S. Oral Herbal therapies for treating osteoarthritis. Cochrane Database Syst Rev. 2014. (5): CD002947.
Placebo-controlled Randomized Clinical Trial onthe Immunomodulating Activities of Low- andHigh-Dose Bromelain after Oral Administration New Evidence on the Antiin flammatory Mode of Action of Bromelain
Potential role of bromelain in clinical and therapeutic applicationsRathnavelu V, Alitheen N, Sohila S et al. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016. 5(3):283–288.
Potential Therapeutic Effects of Curcumin the Anti-inflammatory Agent Against Neurodegenerative Cardiovascular Pulmonary Metabolic Autoimmune and Neoplastic DiseasesAggarwal BB, Harikumar KB. Potential Therapeutic Effects of Curcumin, the Anti-inflammatory Agent, Against Neurodegenerative, Cardiovascular, Pulmonary, Metabolic, Autoimmune and Neoplastic Diseases. Int J Biochem Cell Bio. 2009. 41(1): 40-59.
Properties and Therapeutic Application of Bromelain
Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritisFarid R, Mirfeizi Z, Mirheidari M et al. Pycnogenol supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 2007. 27(11):692‐7.
Randomized Double Blind Trial of an Extract from the Pentacyclic Alkaloid-Chemotype of Uncaria tomentosa for the Treatment of Rheumatoid Arthritis
Review on Sustained Relief of Osteoarthritis Symptoms with a Proprietary Extract from Pine Bark
Role of Curcumin in Common Musculoskeletal Disorders a Review of Current Laboratory, Translational, and Clinical DataPeddada KV, Peddada KV, Shukla SK, et al. Role of Curcumin Musculoskeletal Disorders: A Review of Current Laboratory, Translational, and Clinical Data. Orthopaedic Surgery. 2015. 7(3): 222-31.
Safety and Anti-Inflammatory Activity of Curcumin A Component of TumericChainani-Wu N . Safety and Anti-Inflammatory Activity of Curcumin: A Component of Tumeric (Curcuma longa). J Alt Comp Med. 2003. 9(1): 161–168
Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritisNakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis. a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014. 19(6): 933-939.
The aspirin story from willow to wonder drugDesborough M, Keeling D. The aspirin story – from willow to wonder drug. Br J Haematol. 2017 Jun;177(5):674-683.
The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1Miller M, Ahmed S, Bobrowski P et al: The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta. BMC Complement Altern Med. 2006. 6:13.
The Effect of Pycnogenol Supplementation on Plasma C-Reactive Protein Concentration: a Systematic Review and Meta-AnalysisNikpayam O, Rouhani M, Pourmasoumi M et al. the effect of Pycnogenol supplementation on plasma c-reactive protein concentration: a systematic review and meta-analysis. Clin Nutr Res. 2018. 7(2):117-125.
Therapeutic Application of Pineapple ProteaseTochi B, Wang Z, Ying Xu S et al. Therapeutic Application of Pineapple Protease (Bromelain): A Review. Pakistan Journal of Nutrition. 2008. 7(4):513-520.
Therapeutic Roles of Curcumin Lessons Learned from Clinical TrialsGupta SC, Patchva S, Aggarwal BB. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J. 2013. 15(1): 195-218.
Treatment of Low Back Pain Exacerbations with Willow Bark ExtractChrubasik S, Eisenberg E, Balan E et al. Treatment of low back pain exacerbations with willow bark extract: a randomized double- blind study. Am J Med. 2000 Jul;109(1):9-14.
Treatment of low back pain with a herbal or synthetic anti-rheumaticChrubasik S, Kunzel O, Model A et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized controlled study. Willow bark extract for low back pain. Rheumatology . 2001. 40:1388–1393
Treatment of Osteoarthritis with Pycnogenol The SVOS San Valentino Osteo-arthrosis StudyBelcaro G, Cesarone M, Errichi S et al. Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects. Phytother Res. 2008. 22(4):518-23
Uncaria tomentosa acts as a potent TNF alpha inhibitor through NF kappaBAllen-Hall L, Arnason J, Cano P et al. Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB. J Ethnopharmacol. 2010. 127(3):685-93
Variations in C-reactive protein plasma free radicals and fibrinogen values in patients with osteoarthritis treated with PycnogenoBelcaro G, Cesarone M, Errichi S et al. Variations in C‐reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol ® . Redox Report. 2008. 13(6):271‐6.