HYPERTENSION™ Ingredients Research

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A Meta-Analysis of Folic Acid in Combination with Anti-Hypertension Drugs in Patients with Hypertension and HyperhomocysteinemiaWang W, Wang X, Zhang Z et al. A meta-Analysis of Folic Acid in Combination with Anti-Hypertensi on Drugs in Patients with Hypertension and Hyperhomocysteinemia. Front Pharmacol. 2017. 8:585.
A Nutrient-Wide Association Study on Blood PressureTzoulaki I, Patel C, Okamura T et al. A nutrient-wide association study on blood pressure. Circulation. 2012;126(21):2456–2464  
Actions of Quercetin a Polyphenol on Blood PressureMarunaka Y, Marunaka R, Sun H, et al. Actions of Quercetin, a Polyphenol, on Blood Pressure. Molecules. 2017. 22(2): 209  
Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertensionRied K, Frank O, Stocks N. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. 2010. 67(2):144-50.  
Allium sativum facts and myths regarding human healthMajewski M. Allium sativum – facts and myths regarding human health. Rocz Panstw Zakl Hig. 2014. 65(1):1-8.  
Association of Magnesium Intake with High Blood Pressure in Korean Adults
Changes of Blood Pressure and Hemodynamic Parameters after Oral Magnesium Supplementation in Patients with Essential HypertensionBanjanin N, Belojevic G. Changes of Blood Pressure and Hemodynamic Parameters after Oral Magnesium Supplementation in Patients with Essential Hypertension-An Intervention Study. Nutrients. 2018. 10(5).  
Coenzyme Q10 A therapy for hypertension and statin-induced myalgiaWyman M, Leonard M, Morledge T. Coenzyme Q10. a therapy for hypertension and statin-induced myalgia? Cleve Clin J Med. 2010. 77(7):435-42.
Coenzyme Q10 improves blood pressure and glycaemic controlHodgson J, Watts G, Playford D et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr. 2002. 56(11):1137–1142.  
Coenzyme Q10 in cardiovascular diseasePepe S, Marasco S, Haas S et al. Coenzyme Q10 in cardiovascular disease. Mitochondrion. 2007.  7S:154–S167.  
Coenzyme Q10 in the treatment of hypertensionRosenfeldt F, Haas S, Krum H et al. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum Hypertens. 2007. 21(4):297-306.  
Dietary and Plasma Magnesium and Risk of Coronary Heart Disease Among WomenChiuve S, Sun Q, Curhan G et al. Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Assoc. 2013. 2(2):e000114.  
Dose-response relationship between dietary magnesium intake serum magnesium concentration and risk of hypertensionHan H, Fang X, Wei X et al. Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: a systematic review and meta-analysis of prospective cohort studies. Nutr J. 2017.16(1):26  
Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteersTurner B, Mølgaard C, Marckmann P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. Br J Nutr. 2004. 92(4):701-6.  
Effect of Garlic on Blood Pressure A Meta-AnalysisWang HP, Yang J, Qin LQ, et al. Effect of Garlic on Blood Pressure: A Meta-Analysis. J Clin Hypertens (Greenwich). 2015. 17(3): 223-31  
Effect of Grape Polyphenols on Blood PressureLi S, Zhao P, Tian H et al. Effect of Grape Polyphenols on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials. PLoS ONE. 2015. 10(9):e0137665.  
Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-HypertensionRobinson M, Lu B,  Edirisinghe I et al. Effect of Grape Seed Extract on Blood Pressure in Subjects with Pre-Hypertension. J Pharm Nutri Sci. 2012. 2:155-159.  
Effect of grape seed extract on blood pressure in subjects with the metabolic syndromeSivaprakasapillai B, Edirisinghe I, Randolph J et al. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009. 58(12):1743-6.  
Effect of hydrosoluble coenzyme Q10 on blood pressures and Insulin resistance in hypertensive patients with coronary artery diseaseingh R, Niaz M, Rastogi S et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens. 1999. 13(3):203-8.  
Effect of long term supplementation of active garlic allicin in reducing blood pressure in hypertensive subjectsBhardwaj K, Verma M, Verma N et al. Effect of long term supplementation of active garlic allicin in reducing blood pressure in hypertensive subjects. Int J Advances Med. 2017. 2(3):231-234.
Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertensionRas R, Zock P, Zebregs Y et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr. 2013. 110(12):2234-41.  
Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-) hypertensionBrüll V, Burak C, Stoffel-Wagner B, et al. Effects of a quercetin-rich onion skin extract on 24 h ambulatory blood pressure and endothelial function in overweight-to-obese patients with (pre-)hypertension: a randomised double-blinded placebo-controlled cross-over trial. Br J Nutr. 2015. 114(8):1263–1277.  
Effects of Allium sativum (Garlic) on systolic and diastolic blood pressure in patients with essential hypertensionAshraf R, Khan RA, Ashraf I, et al. Effects of Allium Sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci. 2013. 26(5): 859-63.  
Effects of Magnesium Supplementation on Blood PressureZhang X, Li Y, Del Gobbo L et al. Effects of Magnesium Supplementation on Blood Pressure: A Meta-Analysis of Randomized Double-Blind Placebo-Controlled Trials. Hypertension. 2016. 68(2):324-3
Effects of Quercetin on Blood Pressureerban M, Sahebkar A, Zanchetti A et al. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016. 5(7):e002713.  
Efficacy of homocysteine lowering therapy with folic acid in stroke preventionLee M, Hong K, Chang S et al. Efficacy of homocysteine lowering therapy with folic acid in stroke prevention: a meta-analysis. Stroke. 2010. 41(6): 1205-1212.
Folic acid enhances endothelial function and reduces blood pressure in smokersMangoni A, Sherwood R, Swift C et al. Folic acid enhances endothelial function and reduces blood pressure in smokers: a randomized controlled trial. J Intern Med. 2002. 252(6): 497-503
Free radicals and grape seed proanthocyanidin extract: importance in human health and disease preventionBagchi D, Bagchi M, Stohs S et al. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology. 2000. 148(2-3):187-97.
Grape Polyphenols Reduce Blood Pressure and Increase Flow-Mediated Vasodilation in Men with Metabolic SyndromeBarona J, Aristizabal J, Blesso C et al. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012. 142:1626-32.  
Grape Polyphenols’ Effects in Human Cardiovascular Diseases and DiabetesRasines-Perea Z, Teissedre P. Grape Polyphenols’ Effects in Human Cardiovascular Diseases and Diabetes. Molecules. 2017. 22(1):68.  
Grape Seed Procyanidins in Pre- and Mild HypertensionBelcaro G, Ledda A, Hu S. Grape seed procyanidins in pre- and mild hypertension: a registry study. Evid Based Complement Alternat Med. 2013. 2013: 313142.
High-Dose Folic Acid Acutely Improves Coronary Vasodilator Function in Patients With Coronary Artery DiseaseTawakol A, Migrino R, Aziz K et al. High-dose folic acid acutely improves coronary vasodilator function in patients with coronary artery disease. J Am Coll Cardiol. 2005. 45(10):1580–1584.    
Magnesium and Vascular Changes in HypertensionCunha A, Umbelino B, Correia M et al. Magnesium and vascular changes in hypertension. Int J Hypertens. 2012. 2012:754250.
Magnesium in Disease Prevention and Overall HealthVolpe S. Magnesium in disease prevention and overall health. Adv Nutr. 2013. 4(3):378S–83S.
Mechanisms underlying the antihypertensive effects of garlic bioactivesShouk R, Abdou A, Shetty K et al. Mechanisms underlying the antihypertensive effects of garlic bioactives. Nutr Res. 2014. 34(2):106-15.  
MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adultsQin X, Li J, Cui Y et al. MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults. Nutr J. 2012;11:2.
MTHFR Gene and Serum Folate Interaction on Serum Homocysteine LoweringHuang X, Qin X, Yang W et al. MTHFR685. gene and serum folate interaction on serum homocysteine lowering prospect for precision folic acid treatment. Arterioscler Thromb Vasc Biol. 2018. 38(3):679-
Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced HypertensionOzarowski M, Mikolajczak PL, Kujawski r, et al. Pharmacological Effect of Quercetin in Hypertension and Its Potential Application in Pregnancy-Induced Hypertension: Review of In Vitro, In Vivo, and Clinical Studies. Evid based Complement Altern Med. 2018. 2018: 742148  
Potential of garlic (Allium sativum) in lowering high blood pressure mechanisms of action and clinical relevanceRied K, Fakler P. Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance. Integr Blood Press Control. 2014. 7: 71-82.  
Potential role of coenzyme Q10 in health and disease conditionsRodick T, Seibels D, Babu J et al. Potential role of coenzyme Q10 in health and disease conditions. Nutrition and Dietary Supplements. 2018. 10:1-11.  
Quercetin lowers plasma uric acid in pre-hyperuricaemic malesShi Y, Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: a randomised, double-blinded, placebo-controlled, cross-over trial. Br J Nutr. 2016. 115(5):800-6.  
Quercetin Reduces Blood Pressure in Hypertensive SubjectsEdwards RL, Lyon T, Litwin SE, et al. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007. 137(11): 2405-11.  
Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotypEgert S, Bosy-Westphal A, Seiberl J, et al. Quercetin reduces systolic blood pressure and plasma oxidized low-density lipoprotein concentrations in overweight subjects with high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study. Br J Nutr. 2009. 102(7): 1065-74.  
Quercetin: A Treatment for HypertensionLarson AJ, Symons JD, Jalili T. Quercetin – A Treatment for Hypertension?- A Review of Efficacy and Mechanisms. Pharmaceuticals (Basel). 2010. 3(1): 237-250.  
Randomized Trial of Folic Acid for Prevention of Cardiovascular Events in End-Stage Renal DiseaseWrone E, Hornberger J, Zehnder J et al. Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease. J Am Soc Nephrol. 2004. 15(2): 420-6.  
Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older menRotter I, Kosik-Bogacka D, Dołęgowska B et al. Relationship between serum magnesium concentration and metabolic and hormonal disorders in middle-aged and older men. Magnes Res. 2015. 28(3):99-107.  
Role of coenzyme Q10 (CoQ10) in cardiac disease hypertension and Meniere-like syndromeKumar A, Kaur H, Devi P et al. Role of coenzyme Q10 (CoQ10) in cardiac disease, hypertension and Meniere-like syndrome. Pharmacology & Therapeutics. 2009. 124:259–268.  
The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensivesRied K, Travica N, Sali A. The effect of aged garlic exctract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives. the AGE at Heart Trail.  Integrated Blood Pressure Control 2016 9:9–21  
The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney diseaseJardine MJ, Kang A, Zoungas S, et al. The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis. BMJ. 2012. 344: e3533
The History of Coenzyme Q10 ResearchMorrill R. The History of Coenzyme Q10 Research. Denmark: Schweitzer A/S. 2019. Accessed 29 April 2019.  
The Role of Magnesium in Hypertension and Cardiovascular Disease
The role of nutrition and nutraceutical supplements in the prevention and treatment of hypertensionHouston M. The role of nutrition and nutraceutical supplements in the prevention and treatment of hypertension. A review. Clin. Pract. 2013. 10(2), 209–229.  
Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertensionSobenin I, Andrianova I, Fomchenkov I et al. Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. Hypertens Res. 2009. 32(6):433-7.